Important Information Of Premarin
Premarin is a member of the Conjugated Estrogens group of drugs, based on the female sex hormone estrogen. Estrogen is a hormone essential to the female physiology, on which many of the female-specific body function are based. Among the disorders that may occur when the estrogen quantity becomes insufficient, some examples are: menopause, infertility, and some Breast Cancer types, and ovary function deficiencies, degeneration of the vagina or urethra. The male human body also needs estrogen to function properly, insufficient quantities of this hormone leading to prostate cancer.
If you are using or are considering using PREMARIN only to treat vaginal symptoms, consider topical therapies first. If you are using or are considering using PREMARIN only to prevent osteoporosis due to menopause, talk with your healthcare provider about whether a different treatment or medicine without estrogens might be better for you. PREMARIN should be used at the lowest effective dose and for the shortest duration consistent with your treatment goals and risks.
Premarin Indications
Premarin is mainly prescribed for the treatment of such disorders as:
- moderate or severe vasomotor symptoms associated with the menopause
- moderate or severe symptoms of vaginal or vulvar atrophy associated with the menopause
- hypoestrogenism due to hypogonadism, castration or primary ovarian failure
- some types of Breast Cancer
- advanced androgen-dependent carcinoma of the prostate
- prevention of postmenopausal osteoporosis – in carefully selected cases.
There are a number of other cases in which Premarin can be prescribed, so if you want to know more about why you have been prescribed this drug, consult your personal health care specialist.
Premarin Uses
This medication is a female hormone. It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.
Certain estrogen products may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other medications (such as raloxifene, bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer. These medications should be considered for use before estrogen treatment.
Certain estrogen products may also be used by men and women to treat cancers (certain types of prostate cancer, breast cancer that has spread to other parts of the body) and by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure).
How to use Premarin
Read the Patient Information Leaflet if available from your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor. You may take it with food or right after a meal to prevent stomach upset.
If you are taking the extended-release tablets, do not crush, chew, or dissolve them. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
The dosage is based on your medical condition and response to treatment.
Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day as directed. Follow your dosing schedule carefully. Do not increase your dose or take this medication more often or for a longer time than directed.
Premarin Side Effects
One of the most serious side effects associated with Premarin treatment is the increased risk of developing cancer of the uterus, through development of endometrial hyperplasia. However, this effect can be countered by taking progestins.
Other serious side effects of Premarin use are:
- Increased risk of heart attacks or stroke
- Increased chance of developing Breast Cancer
- Increased chance of developing blood clots in the lungs or legs
- Allergic reactions (such as difficulty breathing, hives, rashes, swelling of the face, tongue or lips)
- Chest pains, shortness of breath
- Painful swollen legs
- Abnormal vaginal bleeding
- Pain, tenderness and swelling of the abdomen
- Severe headaches, blurred vision, trouble in speech, dizziness
- Jaundice
- Breast lumps
Should you happen to experience any of the above symptoms, immediately stop Premarin use and contact your personal health care specialist.
Other side effects that may occur, with less grave consequences, are:
- Nausea
- Swollen or tender breasts
- Acne or skin changes
- A decrease in the sex drive
- Headaches, migraines
- Bloating through water retention
- Depression
- Changes in the menstrual cycle
Should you experience any of these, consult your health care specialist to establish the appropriate course of action.
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