What is bacteriostatic Water?
A bacteriostatic agent or bacteriostat, abbreviated Bstatic, is a biological or chemical agent that stops bacteria from reproducing, while not necessarily killing them otherwise. Depending on their application, bacteriostatic antibiotics, disinfectants, antiseptics and preservatives can be distinguished. When bacteriostatic antimicrobials are used, the duration of therapy must be sufficient to allow host defense mechanisms to eradicate the bacteria. Upon removal of the bacteriostat, the bacteria usually start to grow again. This is in contrast to bactericides, which kill bacteria.[1]Bacteriostats are often used in plastics to prevent growth of bacteria on surfaces. Bacteriostats commonly used in laboratory work include sodium azide (which is acutely toxic) and thiomersal (which is a mutagen in mammalian cells).
Bacteriostatic Water for Injection is supplied in a multiple-dose 30 mL plastic fliptop vial that is plastic and not pressurized. It is not used for neonatal medications because of possible blood pressure changes and toxicity of benzyl alcohol. If Bacteriostatic Water is injected intravenously without any diluted compound, it may cause some red blood cell lysis because it is not isotonic. Bacteriostatic Water usually does not interact with other drugs; however, some drugs for injection may be incompatible. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant before receiving Bacteriostatic Water. Consult your doctor before breastfeeding.
Bacteriostatic Water antibiotics
Bacteriostatic antibiotics limit the growth of bacteria by interfering with bacterial protein production, DNA replication, or other aspects of bacterial cellular metabolism. They must work together with the immune system to remove the microorganisms from the body. However, there is not always a precise distinction between them and bactericidal antibiotics; high concentrations of some bacteriostatic agents are also bactericidal, whereas low concentrations of some bacteriocidal agents are bacteriostatic.This group includes:
- Tetracyclines
- Sulfonamides
- Spectinomycin
- Trimethoprim
- Chloramphenicol
- Macrolides
- Lincosamides
- Clindamycin
- Ethambutol
- Nitrofurantoin
- Novobiocin
- Tigecycline
- Oxazolidinone
Bacteriostatic Water Drug Interactions
Some drugs for injection may be incompatible in a given vehicle, or when combined in the same vehicle or in a vehicle containing benzyl alcohol. Consult with pharmacist, if available.
Use aseptic technique for single or multiple entry and withdrawal from all containers.
When diluting or dissolving drugs, mix thoroughly and use promptly.
Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute.
Do not use unless the solution is clear and seal intact.
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